Plenary Lecture 7



Title: Phosphodieasterase Inhibitors as a Potential Treatment for
Neglected Parasitic Diseases
.
Professor Rob Leurs

Vrije University, Netherlands
 

 

Lecture Summary: Cyclic nucleotide phosphodiesterases (PDEs) have emerged as attractive molecular targets for a novel treatment for a variety of Neglected Parasitic diseases, including African trypanosomiasis, Chagas disease, and malaria. For example, both genetic knock-down and chemical inhibition of PDE activity resulted in halted proliferation and eventually elimination of Trypanosoma brucei (Tbr), the causative agent of African sleeping sickness. The vast knowledge and generated expertise within the field of human PDEs provides a shortcut to high-affinity inhibitors of parasitic PDEs. We have brought together a public-private consortium with PDE experts, medicinal chemists and parasitologists to effectively target parasitic PDEs.

The PDE4NPD project is an EU-funded platform to develop new chemical entities targeting parasitic PDEs. The PDE4NPD project is supported by the European Union 7th Framework Program (FP7/2007-2013) under grant agreement n° 602666 and involves ten consortium members and research labs in seven countries (www.PDE4NPD.eu). In this presentation we will show our progress in developing approaches to combat parasitic diseases by both a phenotypic and target-based approaches.

 

Acknowledgments: The PDE4NPD project is supported by the European Union 7th Framework Program (FP7/2007-2013) under grant agreement n° 602666.